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In Brief: Alternatives to Bicillin L-A
The Medical Letter on Drugs and Therapeutics • January 5, 2026; (Issue 1745)
On July 10, 2025 Pfizer issued a voluntary recall
of certain lots of long-acting intramuscular (IM)
benzathine penicillin G (Bicillin L-A) due to particulates
identified during visual inspection. The CDC...
On July 10, 2025 Pfizer issued a voluntary recall
of certain lots of long-acting intramuscular (IM)
benzathine penicillin G (Bicillin L-A) due to particulates
identified during visual inspection. The CDC has
issued a "Dear Colleague Letter" to alert healthcare
providers about the recall and provide advice on how
to manage the potentially limited supply of the drug for
treatment of syphilis, which has been increasing in the
US.2 Benzathine penicillin G is also used for treatment
of group A streptococcal pharyngitis and prophylaxis
of rheumatic fever.